The Lilywhites came through Thursday's Europa League clash against Hoffenheim with a 3-2 victory to their name and also welcomed Fraser Forster and Rodrigo Bentancur back to their ranks following illness and a head injury respectively.
However, Yves Bissouma (knock), Pape Sarr (knock), Dominic Solanke (knee), Guglielmo Vicario (ankle), Cristian Romero (thigh), Micky van de Ven (hamstring), Wilson Odobert (hamstring), Destiny Udogie (hamstring), Brennan Johnson (calf) and Timo Werner (hamstring) all missed out, and only the former two might have a shot of coming back for Sunday.
Postecoglou is guaranteed to receive two defensive fillips in the shape of Antonin Kinsky and Djed Spence, though, and the refreshed pair could come straight back into the Lilywhites' lineup.
Brandon Austin and Archie Gray might be the unfortunate souls sacrificed, as Ben Davies is a more natural fit at centre-back alongside Radu Dragusin, while Pedro Porro should be a shoo-in on the right.
Sarr's prospective return might allow Postecoglou to rest Lucas Bergvall as the Senegal international joins Bentancur and James Maddison in the centre, but the front three is sure to remain unchanged.
A first Premier League start of the season awaits Richarlison up front in place of Solanke, and the Brazilian ought to be flanked by Dejan Kulusevski and Son Heung-min, who netted his 171st and 172nd Spurs goals in midweek.
Tottenham Hotspur possible starting lineup:
Kinsky; Porro, Dragusin, Davies, Spence; Sarr, Bentancur, Maddison; Kulusevski, Richarlison, Son
Written by
Ben Knapton