The Lilywhites were without both Dominic Solanke (ankle) and Richarlison (unspecified) for their 2-1 loss to Newcastle United two weekends ago, and the latter will not return for another couple of weeks.
However, there is hope that £65m man Solanke will be able to make his North London derby debut from the first whistle, which would lead to a rejig in the final third for the hosts.
James Maddison and Son Heung-min - who has scored eight times against Arsenal in the past - are shoo-ins, leaving Dejan Kulusevski and Wilson Odobert to battle for the final offensive spot, a head-to-head that the more experienced former may win.
Spurs suffered a scare over the fitness of Yves Bissouma during the international break, but Postecoglou has a ready-made replacement in the shape of Rodrigo Bentancur, who could now partner Pape Sarr in the middle despite being charged by the FA over his racially insensitive comment about South Koreans.
There is more optimism over the fitness of Micky van de Ven, whose knee problem is expected to settle down in time for him to displace Radu Dragusin alongside Cristian Romero.
Van de Ven's comeback would allow Postecoglou to put out a first-choice backline, as Destiny Udogie and Pedro Porro also form part of Guglielmo Vicario's four-man barrier.
Tottenham Hotspur possible starting lineup:
Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Bentancur; Kulusevski, Maddison, Son; Solanke