Ange Postecoglou's side have not kicked a ball since they suffered a heavy 4-0 defeat away against Newcastle United on April 13, and they are now playing catch-up in the race to secure a top-four finish.
Tottenham currently sit fifth in the Premier League table and six points behind fourth-placed Aston Villa, but that gap can be reduced if Spurs win their two games in hand, starting with a derby showdown with league leaders Arsenal.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of the contest with Mikel Arteta's side, who thrashed Chelsea 5-0 on Tuesday.
Destiny Udogie
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Destiny Udogie has been ruled out for the rest of the season after undergoing surgery on his left quadriceps last week; the Italian will also miss Euro 2024 this summer.
Pedro Porro
Status: Major doubt
Type of injury: Hamstring
Possible return date: April 28 (vs. Arsenal)
Pedro Porro has emerged as a doubt after he was forced off early in the second half of the defeat at Newcastle with a hamstring strain.
Richarlison
Status: Minor doubt
Type of injury: Knee
Possible return date: April 28 (vs. Arsenal)
Richarlison has miss Tottenham's last two games with a knee injury and the Brazilian will be assessed ahead of kickoff.
Fraser Forster
Status: Out
Type of injury: Foot
Possible return date: Unknown
Fraser Forster sustained a foot fracture in training in February and the veteran goalkeeper is likely be unavailable for the rest of the season.
Manor Solomon
Status: Out
Type of injury: Knee
Possible return date: Unknown
Manor Solomon has undergone multiple operations in an attempt to mend a troublesome knee injury and there is currently no timeframe on the attacker's potential return.
Ryan Sessegnon
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon had only just recovered from one severe injury before picking up a season-ending hamstring problem while playing for the Under-21s earlier this year, and the 23-year-old has months of rehabilitation ahead of him.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham Hotspur have no suspended players for this match.