The South American giants will enter the match off the back of a 1-0 victory over England, with 17-year-old Endrick scoring the only goal of the contest at Wembley.
Endrick is expected to again be involved off the bench against Spain, but there could be a change in the final third of the field, with Pepe Aquino potentially being given the nod.
Vinicius Junior and Rodrygo should retain their spots but might only play the opening 45 minutes, with head coach Dorival Junior expected to protect the fitness of the key Real Madrid duo.
Douglas Luiz and Bremer are also pushing for positions in the XI, while Porto's Galeno will be hoping to make his international debut at some stage of the contest.
The absences of goalkeepers Alisson Becker and Ederson opened the door for Bento to debut against England, and the 24-year-old could retain his spot in the side for this contest.
Yan Couto is also pushing to be involved, but Dorival Junior might feel that he needs the experience of Danilo in a defensive position.
Richarlison did not feature against England due to concerns over a knee problem which he picked up while representing Tottenham Hotspur, and it remains to be seen whether the forward is involved in this game.
Brazil possible starting lineup: Bento; Danilo, Bremer, Beraldo, Wendell; Paqueta, Guimaraes, Luiz; Pepe, Rodrygo, Vinicius