The Saints are winless after seven matches and sit 19th in the top-flight table, whilst visitors Leicester have tasted success on just the single occasion so far this season.
That maximum arrived just prior to the international break for the Foxes, though, with Steve Cooper's troops recording a narrow home win over Bournemouth at the King Power Stadium.
Whilst Leicester were conquering the Cherries, Southampton were suffering their sixth defeat from seven in North London, where title challengers Arsenal won 3-1.
Russell Martin's side took a surprise lead through summer arrival Cameron Archer, however efforts from Kai Havertz, Gabriel Martinelli and Bukayo Saka secured a comeback victory for the Gunners.
Southampton versus Leicester statistic that will worry Saints fans
Although Southampton's run without victory is currently at seven matches in 2024-25, their winless streak in the Premier League goes back well into their relegation campaign of 2022-23.
Amazingly, the South Coast club's most recent maximum in the top flight of English football arrived against Saturday's opponents Leicester on March 4, 2023.
Despite Brendan Rodgers's Foxes dominating possession at St Mary's on the evening, a solitary second-half strike from Carlos Alcaraz was enough to win the contest for the Saints.
From that point, Southampton would endure a 13-game winless spell until the end of the 2022-23 season, earning just four draws along the way.
Since that success at the expense of Leicester over 19 months ago, the Saints have failed to win any of their 20 Premier League matches, collecting only five points.
Leicester looking to make it three on the spin
Despite Southampton winning the most recent top-flight match between the sides, Leicester are arguably favourites heading into this weekend considering their matchups with Martin's men in the Championship last term.
The Foxes did the double over the South Coast outfit by an aggregate scoreline of 9-1, including a 4-1 success at St Mary's in September 2023.
That being said, Leicester were a different beast in the second tier under the leadership of head coach Enzo Maresca, who was poached by Chelsea over the summer.