Enzo Maresca's men extended their unbeaten run to six games by beating Aston Villa 3-0 at the weekend, and remain in the top four, only behind Arsenal courtesy of alphabetical order.
Opponents Southampton are currently cut adrift at the bottom, four points behind the nearest team, after they could only take a point away at Brighton & Hove Albion on Friday, despite having a goal disallowed for a contentious offside decision.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of making the trip to the South Coast.
Wesley Fofana
Status: Out
Type of injury: Hamstring
Possible return date: January 11 (vs. Morecambe)
Fofana sustained a hamstring injury in the weekend win over Aston Villa and manager Maresca has confirmed he will miss the next four-to-five weeks as a result.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
After missing the first few months of the campaign, right-back James is once again facing a few weeks on the sidelines with a hamstring injury, having played just four games this season.
Omari Kellyman
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Kellyman is yet to feature for Chelsea since joining from Aston Villa in the summer, and will remain on the sidelines for the foreseeable future due to a hamstring issue.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues heading into this contest.