The Portuguese stopper conceded two penalties in the 4-2 defeat against Bournemouth at the weekend, with the first of the two certainly solely down to his error.
Sam Johnstone returned to the squad after injury at the weekend too, and could be in line to start following a dip in form for Sa, who is part of the league's leakiest defence.
Craig Dawson made his comeback from injury off the bench against the Cherries, and it was his woeful back pass that led to the third Bournemouth penalty, but the experienced defender is still likely to return to the starting XI.
With Santiago Bueno back to full fitness, Toti Gomes could see his place in the side under threat, especially after being hooked early in that weekend defeat, with the defender the other guilty party in conceding one of the three penalties.
One of Wolves' more consistent performers in defence will be missing due to suspension though, with Nelson Semedo now banned after picking up his fifth booking of the season at the weekend.
Slightly further forward, Boubacar Traore is still not ready to return, with manager Gary O'Neil suggesting that he will not be back until just after Christmas.
In attack, Wolves are spoilt for choice, with Pablo Sarabia and Hwang Hee-chan now back in the squad after injury.
One could start alongside the in-form duo Matheus Cunha and Jorgen Strand Larsen in a three-pronged attack at Goodison, with attacking prowess likely to be the only way Wolves can win this encounter.
Strand Larsen scored the two goals in the Bournemouth defeat, while Cunha has been one of the standout performers in the league so far this season, netting two goal-of-the-month contenders against Fulham in their last away outing.
Cunha also scored and provided an assist in the 3-0 win over Everton at home in December, but it is on the road where the Brazilian has much success, with 70% of his Premier League goals coming away from home - only Erling Haaland has more away PL goals since the start of last season.
Wolverhampton Wanderers possible starting lineup:
Johnstone; Lemina, Bueno, Dawson; R Gomes, J Gomes, Andre, Ait-Nouri; Sarabia, Strand Larsen, Cunha
FC Oleksandriya 
Dynamo Kyiv 
VFL Wolfsburg 
1899 Hoffenheim 
Ajax 
Utrecht 
Everton 
Wolverhampton 
Manchester City 
Nottingham Forest 
Newcastle 
Liverpool 
Southampton 
Chelsea 
RB Leipzig 
Eintracht Frankfurt 
Rangers 
Kilmarnock 
Fiorentina 
Empoli 
Aberdeen 
Celtic 
Athletic Bilbao 
Real Madrid 
Ejea 
Valencia 
Arsenal 
Manchester Utd 
Shakhtar Donetsk 
Vorskla Poltava 
Cacereno 
Atletico Madrid 
Lazio 
Napoli 
Ue Olot 
Sevilla 
Bournemouth 
Tottenham 
Inter 
Parma 
Valenciennes 
Bordeaux 
PSV 
Twente 
Atalanta 
AC Milan 
Auxerre 
Paris Saint Germain 
Spartak Moscow 
Nizhny Novgorod 
Bayer Leverkusen 
FC ST. Pauli 
Bayern Munich 
FC Heidenheim 
FC Augsburg 
VFL Bochum 
Werder Bremen