This will be first meeting between the two sides, and City's first ever trip to Slovakia for a European encounter, facing competition debutants and rank outsiders Slovan.
The visitors will see this as an opportunity to improve a recent run of form which has seen the English champions win just one of their last four games in all competitions, after they were held by Newcastle United on Saturday.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the clash with Slovan Bratislava, who enter this fixture in the back of a 5-1 defeat to Celtic on matchday one in their UCL debut.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Man City confirmed on Wednesday that Rodri tore his anterior cruciate ligament against Arsenal last weekend, and Pep Guardiola has confirmed that his season is now over.
Kevin De Bruyne
Status: Minor doubt
Type of injury: Groin
Possible return date: October 1 (vs. Slovan Bratislava)
De Bruyne failed a late fitness test ahead of the trip to Newcastle United at the weekend, and has now missed Man City's last three matches since being forced off against Inter Milan, but even thohugh he could be fit to return here, manager Guardiola may hold him back ahead of the clash against Fulham at the weekend.
Nathan Ake
Status: Out
Type of injury: Thigh
Possible return date: October 20 (vs. Wolverhampton Wanderers)
Central defender Ake will be out of action until after the next international break due to the thigh problem that he picked up on international duty with Holland earlier this month.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Bobb had a fine preseason with City, but suffered a nasty leg injury on the eve of the new campaign, and is set to remain out until the new year.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.