Meanwhile, the away side make the trip aiming to continue their recent resurgence which has seen them win five of their last six matches across all competitions.
Match preview
Fortuna Sittard were left red-faced last time out as they fell to a 4-0 defeat against Sparta Rotterdam at the Sparta Stadion Het Kasteel on Saturday.
Danny Buijs's men went behind to Arno Verschueren's opener just shy of the half-hour mark before a second-half double from Tobias Lauritsen and Camiel Neghli's strike put the result beyond doubt.
Consequently, the Fortunezen have dropped down to 10th in the Eredivisie table but remain just two points shy of the final European place.
On the menu next is the challenge of an opposing outfit who have lost just one of the last seven editions of this fixture dating back to 2021.
Unbeaten in their last three matches on home turf, Tuesday's hosts have proven themselves to be a tough nut to crack in front of their fans.
NEC recorded arguably their most impressive result of the season as they ran out 3-1 winners against PSV Eindhoven at Stadion de Goffert on Saturday.
After going behind to Johan Bakayoko's opener, Rogier Meijer's men hit back through Lasse Schone before second-half strikes from Kodai Sano and Sylla Sow completed a remarkable turnaround.
With 42 points amassed from 27 matches so far, the Eniesee sit sixth in the standings and are well on course to secure a place in the Conference League playoffs semi-finals.
Having netted nine times across their last four away outings, Tuesday's visitors will be looking to put on another fine attacking display on enemy territory.
Fortuna Sittard Eredivisie form:
L
W
W
D
W
L
NEC Eredivisie form:
D
W
W
W
L
W
NEC form (all competitions):
W
W
W
W
L
W
Team News
Dutch duo Kas de Wit and Dirk Proper remain out of contention for NEC Nijmegen but the latter is closing in on a return to full fitness.
Bas Dost is also sidelined for the away side due to a heart problem, while Suriname international Tjarron Chery misses out with a muscle problem.
Fortuna's Marko Lazetic could be set for a first club appearance since November having recently returned to action with the Serbia Under-21s.
However, Arianit Ferati is still unavailable as he continues to nurse a thigh problem which has seen him miss each of the hosts' last three matches.
Fortuna Sittard possible starting lineup:
Verrips; Dijks, Siovas, Guth, Pinto; Duarte, Ozyakup; Cordoba, Oratmangoen, Lonwijk; Sierhuis
NEC possible starting lineup:
Cillessen; Van Rooy, Sandler, Nuytinck, Verdonk; Hoedemakers, Schone; Gonzalez, Sano, Baas; Sow