The hosts, who are bottom of Group C, are already out of the competition with nothing left to play for, while the visitors can put themselves in a better position to advance with a win here.
Match preview
Real Tomayapo have endured a poor Copa Sudamericana campaign which has seen them fail to win any match in the competition so far, confirming their exit.
The Bolivian side made it into the group stage after a penalty shootout victory over Wilstermann following a goalless draw in normal time.
However, a defeat to Delfin in their opening match showed they needed to raise their game if they would leave the group stage. A draw with Internacional in their second match left them with some hope but things went downhill from there.
Back-to-back losses to Belgrano followed by a defeat against Delfin ended any hopes of progressing in the competition. Now they have nothing at stake to play for except pride when they welcome Internacional to Estadio IV Centenario on Wednesday.
Internacional returned to winning ways with a 1-0 victory over Cuiaba in the Brasileiro on Saturday courtesy of Hugo Mallo's second-half strike.
Eduardo Coudet will hope his side can take this momentum into Wednesday's Copa Sudamericana match as they need a win to increase their chances of advancing into the next round.
After recording goalless draws in their opening two games of the competition, the Brazilian side picked up a win against Delfin to reach five points. However, they fell to their first defeat against group leaders Belgrano, leaving them third in the table and in a tricky situation with two matches left to play.
Finding the net was initially an issue for Internacional in the first two games, which included the reverse fixture against Tomayapo. They, however, seem to have slowly sorted that with three goals in the following two matches in the group.
Scoring goals and picking up a win here is important for the Reds as it will put them level on points with second-placed Delfin, who have just one game left, or even above them if they can win by at least a three-goal difference. A win here will leave them with all to play for against Delfin in the final group match.
Real Tomayapo Copa Sudamericana form:
W
L
D
L
L
L
Internacional Copa Sudamericana form:
D
D
W
L
Internacional form (all competitions):
W
L
W
D
L
W
Team News
Tamayapo midfielder Sergio Villamil was substituted against Delfin after sustaining an injury, making him a doubt for this match.
Agustin Graneros opened his account in the competition last time out and should lead the attack once again with Leandro Maygua providing support.
Internacional are expected to remain without 21-year-old forward Lucca until later this month.
With Lucca out, Rafael Borre and Enner Valencia should start together in attack for the third straight game.
Wanderson and Ivan are both sidelined with knee injuries, with the former expected to return within the next few days while the latter will miss the next few weeks.
Real Tomayapo possible starting lineup:
Arancibia; Justiniano, Cantillo, Rioja, Villamil; Cuiza, Alcaraz, Aviles, Noble; Maygua; Graneros
Internacional possible starting lineup:
Rochet; Renan, Mercado, Vitao, Mallo; Mauricio, Maia, Wesley, Henrique; Borre, Valencia