Carlo Ancelotti's side beat Real Sociedad 2-0 in their last league fixture, before recording a 3-1 victory over Stuttgart in the Champions League on Tuesday night.
Los Blancos have picked up 11 points from their opening five matches of the 2024-25 La Liga campaign, which has left them third in the table, four points behind the leaders Barcelona.
Here, Sports Mole rounds up Real Madrid's injury and suspension news ahead of their contest with Espanyol, who are 11th in the division, having collected seven points from their first five games.
David Alaba
Status: Out
Type of injury: Knee
Possible return date: Unknown
Alaba suffered an ACL injury towards the end of last year, which required an operation, and he then underwent further surgery in the middle of May. The centre-back is making solid progress in his recovery, but he will not be available for selection until the end of the year.
Eduardo Camavinga
Status: Major doubt
Type of injury: Knee
Possible return date: September 21 (vs. Espanyol)
Camavinga suffered a knee injury in a training session ahead of the UEFA Super Cup in August, which has seen him miss the early stages of the new La Liga season, but the midfielder has a slight chance of being back in the squad for this match.
Dani Ceballos
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Ceballos picked up an ankle injury during Real Madrid's clash with Real Betis before the recent international break, and the midfielder is set to be on the treatment table until at least the end of next month.
Brahim Diaz
Status: Out
Type of injury: Abductor
Possible return date: Unknown
Real Madrid will be missing Brahim until at least the middle of November due to the hip abductor injury that he picked up during his side's league fixture with Real Sociedad last weekend.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for their clash with Espanyol.