Xavi's side suffered a 4-1 loss to Paris Saint-Germain in the second leg of their last-eight European contest on Tuesday, which saw them knocked out of the tournament 6-4 on aggregate.
The Catalan outfit will now switch their attention back to La Liga, where they sit second in the table, eight points behind leaders Real Madrid, who beat Manchester City to make the Champions League semi-finals.
Here, Sports Mole rounds up Barcelona's latest injury and suspension news ahead of El Clasico.
Gavi
Status: Out
Type of injury: Knee
Possible return date: Unknown
Gavi sustained a serious knee injury while representing Spain towards the end of last year, and the midfielder will not be available for selection until the 2024-25 campaign.
Alejandro Balde
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Balde underwent a hamstring operation at the end of January, and the club's first-choice left-back will also be unavailable for selection until the 2024-25 campaign.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for this match and will welcome back both Andreas Christensen and Sergi Roberto, with the pair missing out against PSG due to European bans.
Bukovina Chernivtsi 
Dynamo Kyiv 
Polissya Zhytomyr 
Shakhtar Donetsk 
Cagliari 
Fiorentina 
Genoa 
Lazio 
Parma 
Juventus 
Torino 
Udinese 
Arsenal 
Crystal Palace 
Inter 
AC Milan 
Benfica 
Tirsense 
Getafe 
Real Madrid 
AZ Alkmaar 
Nac Breda 
Osasuna 
Sevilla 
Twente 
PSV 
Atletico Madrid 
Rayo Vallecano 
Carrarese 
Sampdoria 
Rouen 
Bordeaux 
Paris Saint Germain 
Nice 
Feyenoord 
Pec Zwolle 
Chelsea 
Everton 
Dundee Utd 
Celtic 
Bayer Leverkusen 
FC Augsburg 
Bayern Munich 
FSV Mainz 05 
1899 Hoffenheim 
Borussia Dortmund 
VFL Wolfsburg 
SC Freiburg 
FC Rostov 
Lokomotiv Moscow 
Wolverhampton 
Leicester 
ST Mirren 
Rangers 
La Roche 
Spartak Moscow 
CSKA Moscow 
Eintracht Frankfurt 
RB Leipzig