A sold-out crowd of 61,000 supporters could see the 18-year-old donning the colours of his new employers for the first time since moving from Palmeiras in his homeland.
On a negative note for those paying fans in Chicago, Carlo Ancelotti is set to be without a number of his superstar players for the clash with the Rossoneri.
Brazilian trio Vinicius Jr, Rodrygo and Eder Militao are joining up with the Madrid squad at a later date, meaning that they will be unavailable on Wednesday.
All three played a major part for Brazil at this summer's Copa America in the United States, where Dorival Junior's troops fell short of pan-American glory.
Germany's Antonio Rudiger has been named in the initial travelling squad for Los Blancos and could make his first appearance since Die Mannschaft's Euro 2024 quarter-final loss to Spain.
Absences at the top end of the pitch could allow some of Madrid's youngsters to take centre stage at Soldier Field, including academy graduate Juanmi Latasa.
Real Madrid possible starting lineup: Courtois; Vazquez, Vallejo, Rudiger, Garcia; Ceballos, Paz, Guler; Diaz, Endrick, Latasa
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