Carlo Ancelotti's side finished 13 points clear of second-placed Barcelona in last season's La Liga table, while they also won the Champions League during an impressive campaign.
The season is starting earlier than usual due to the 2022 World Cup, which will take place in November and December.
August 12 will be the official start date of the new La Liga season, while the final set of fixtures will be held on June 4, with all matches kicking off at the same time.
Real Madrid will face Almeria, Celta Vigo and Espanyol in their first three league matches of the campaign, all of which are away, with their first home game taking place against Real Betis in early September.
Los Blancos will take on Barcelona in October and March, while they will face capital rivals Atletico Madrid in the Madrid derby in September and February.
Real Madrid's 2022-23 La Liga fixtures in full:
August
14 - Almeria (A)
21 - Celta Vigo (A)
28 - Espanyol (A)
September
4 - Real Betis (H)
11 - Mallorca (H)
18 - Atletico Madrid (A)
October
2 - Osasuna (H)
9 - Getafe (A)
16 - Barcelona (H)
19 - Elche (A)
23 - Sevilla (H)
30 - Girona (H)
November
6 - Rayo Vallecano (A)
9 - Cadiz (H)
December
31 - Real Valladolid (A)
January
8 - Villarreal (A)
14 - Valencia (H)
22 - Athletic Bilbao (A)
29 - Real Sociedad (H)
February
2 - Mallorca (A)
12 - Elche (H)
19 - Osasuna (A)
26 - Atletico Madrid (H)
March
3 - Real Betis (A)
12 - Espanyol (H)
19 - Barcelona (A)
April
2 - Real Valladolid (H)
9 - Villarreal (H)
16 - Cadiz (A)
23 - Celta Vigo (H)
26 - Girona (A)
30 - Almeria (H)
May
3 - Real Sociedad (A)
14 - Getafe (H)
21 - Valencia (A)
24 - Real Vallecano (H)
28 - Sevilla (A)
June
4 - Athletic Bilbao (H)