Ange Postecoglou's side are on a four-match winless streak in all competitions, the latest disappointment coming on Sunday as they let slip a two-goal lead against Chelsea to lose in a seven-goal thriller.
Although the North Londoners have fared better in this competition, they know that a win is needed to bolster their hopes of securing a place in the last 16.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with a team in Rangers who are direct rivals for a place in the top eight.
Guglielmo Vicario
Status: Out
Type of injury: Ankle
Possible return date: Unknown
First-choice goalkeeper Vicario remarkably played for over an hour at the Etihad Stadium last month with a broken ankle, which he has since undergone surgery for, and Postecoglou has confirmed that the Italian faces months out of action.
Cristian Romero
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Although Romero made a return from a toe injury against Chelsea, he lasted just 20 minutes courtesy of sustaining what Postecoglou described as an issue with his quad. As it stands, it is unclear how long the World Cup winner will be sidelined for, but he will not feature in this match.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: January 15 (vs. Arsenal)
Richarlison's hamstring problem is expected to render him unavailable until the early stages of January, potentially meaning that he could make his comeback in the next North London derby.
Micky van de Ven
Status: Major doubt
Type of injury: Hamstring
Possible return date: December 12 (vs. Rangers)
Van de Ven made a surprise return from a hamstring injury against Chelsea before being withdrawn in the second half. Although the Netherlands international was seen holding the back of his leg prior to his substitution, Postecoglou has insisted that the defender was suffering with 'nothing significant'.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Just after making a comeback from one hamstring problem, summer signing Odobert sustained an even more severe injury in the same area and will be out for the long-term after undergoing an operation.
Mikey Moore
Status: Major doubt
Type of injury: Illness
Possible return date: December 12 (vs. Rangers)
Teenage sensation Moore has been laid low by a troublesome illness this month, and Postecoglou has conceded that it will be at least the middle of the month before the 17-year-old makes his return.
Ben Davies
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Spurs were handed a further defensive blow last week when Davies sustained a hamstring injury. There is currently every indication that the Wales international could be sidelined for the remainder of 2024.
Brennan Johnson
Status: Minor doubt
Type of injury: Illness
Possible return date: December 12 (vs. Rangers)
Johnson needed to be withdrawn shortly after half time against Chelsea due to feeling ill. While the Wales international will now be assessed, he is expected to remain in contention for Thursday night.
TOTTENHAM'S SUSPENSION LIST
With Rodrigo Bentancur's ban only applying to domestic fixtures, Spurs have no suspension issues for this fixture.
Written by
Darren Plant