The Roman giants made a bright start to the new Serie A season before taking just a point from their last two games, while their visitors - beaten Conference League finalists last term - remain unbeaten in the Eredivisie.
Match preview
In Maurizio Sarri's first season in charge of Lazio, the Italian side made their record-equalling ninth appearance in the Europa League group stage, and went onto reach the knockout phase for a seventh time.
Indeed, the Aquile have played 78 times in Europe's second-tier tournament since its inception in 2009 - second only to Villarreal - but they have yet to go all the way, following an exit to Porto in the playoff round of last season's edition.
After suffering another defeat away from home in that tie's first leg at Estadio do Dragao, Lazio have won just one of their last 13 games on the road in Europe, so will be glad to kick off their latest campaign in the familiar surrounds of the Eternal City.
Sarri's side have drawn each of their last three home matches in the Europa League, but generally fare far better at the Olimpico than away from their Roman stronghold.
They lost just three times in the league there last season, and had beaten both Bologna and top-four rivals Inter in the Italian capital before hosting Sarri's former club Napoli on Saturday.
Despite sealing a fifth-placed finish last term, Lazio were not the most reliable of teams, and the same inconsistencies reared their head in a 2-1 loss to Luciano Spalletti's side, in which the home side squandered a lead secured by Mattia Zaccagni's early strike.
While Lazio sit ninth in the early Serie A standings, their opponents - who they last met during the second group stage of the 1999-2000 Champions League - are in flying form; occupying second spot in the Eredivisie.
A goalless draw with Heerenveen aside, Feyenoord have won each of their fixtures by an aggregate scoreline of 14-5, following last weekend's 4-3 win away to Go Ahead Eagles, in which they fought back from going two goals down with only 13 minutes played.
All of which is made more impressive by the necessity for coach Arne Slot to rebuild his side after their impressive run to the inaugural Europa Conference League final, which they ultimately lost to Lazio's arch-rivals Roma.
Slot has seen his squad decimated by big-spending English clubs over the summer, as Tyrell Malacia, Marcos Senesi and Luis Sinisterra all joined Arsenal loanee Reiss Nelson in departing for the Premier League. Star striker Cyriel Dessers upped sticks for Serie A, too.
Those who remain have accrued invaluable experience, though, as Feyenoord played 19 games in the Conference League last season - winning twelve times and losing just twice; the latter loss coming at the final hurdle, in Tirana.
Lazio form (all competitions):
Feyenoord form (all competitions):
Team News
Despite their weekend defeat, and a packed schedule over the coming weeks, Lazio are expected to name a familiar side on Thursday, as they go toe-to-toe with perhaps their chief rivals for Group F's top spot - FC Midtjylland and Sturm Graz are their other opponents.
Nonetheless, veteran winger Pedro is pushing hard for a place in the hosts' front three, while Nicolo Casale hopes to usurp Patric in central defence and make his first start for the club since signing this summer.
Maurizio Sarri has an almost fully-fit squad to choose from, with Marcos Antonio, Matias Vecino and Toma Basic all strong candidates to come into the Biancocelesti's three-man midfield; captain Ciro Immobile - with 24 goals in 40 previous European matches - is likely to lead the line up front.
Meanwhile, Feyenoord's forward line could be composed of Patrik Walemark, Javairo Dilrosun and Brazilian forward Danilo - the latter joined from Ajax in May, and scored twice in the comeback win over Go Ahead Eagles.
Full-backs Marcos Lopez and Lutsharel Geertruida are set to miss the trip to Rome due to injury, but the visitors should otherwise be well-placed to select their strongest side.
Lazio possible starting lineup:
Provedel; Lazzari, Romagnoli, Patric, Hysaj; Milinkovic-Savic, Cataldi, Vecino; Pedro, Immobile, Zaccagni
Feyenoord possible starting lineup:
Bijlow; Pedersen, Trauner, Rasmussen, Hancko; Szymanski, Timber, Kokcu; Walemark, Danilo, Dilrosun