The Danish hosts will be seeking revenge against the Red Devils after suffering a slender 1-0 loss in the reverse fixture at Old Trafford two weeks ago.
Match preview
Copenhagen will have taken plenty of positive from their performance against Man United in matchday three, but they ultimately came away from the red side of Manchester empty handed, as Harry Maguire's second-half header was followed by a dramatic last-minute penalty save from Andre Onana to ensure the Red Devils claimed all three points.
After accumulating just one point from their first three Champions League fixtures, the Lions face an uphill battle to secure a top-two finish in Group A as they currently sit rock bottom of the group and three points adrift of second-placed Galatasaray, who travel to leaders Bayern Munich in their next match.
Since their slender loss at Old Trafford, Jacob Neestrup's side have put together a three-game winning run on the domestic front, with a 4-0 Superliga victory over Hvidovre and a 1-0 win against Midtjylland in the Danish Cup taking place before a 4-2 top-flight success at Randers on Sunday.
An early equaliser from Rasmus Falk was eventually followed by second-half goals from substitute trio Viktor Claesson, Jordan Larsson and Victor Froholdt to help Copenhagen maintain their position at the Superliga summit, sitting four points clear of second-placed Brondby who they face in a top-of-the-table clash on Sunday.
Copenhagen are now preparing to welcome Man United to Parken Stadium for the first time since securing a memorable 1-0 home triumph over the Red Devils in the 2006-07 Champions League group stage - their first-ever victory in the competition that coincidently took place in matchday four.
Repeating that success on Wednesday could prove challenging, though, as the Danish champions have failed to win any of their last 10 meetings with English clubs in European competition, as well as each of their last six Champions League home games, although five of those ended as draws including four 0-0 stalemates.
Following two dreadful 3-0 home defeats to Newcastle United and Manchester City in the EFL Cup and Premier League respectively, Man United looked to be heading for a third successive game without a win or a goal in last weekend's top-flight contest at Fulham.
However, captain Bruno Fernandes stepped up in second-half stoppage time to score the decisive goal in an important 1-0 victory for the Red Devils at Craven Cottage, a result that has slightly alleviated the pressure on manager Erik ten Hag.
Man United were certainly not at their clinical best against an equally goal-shy Fulham outfit, but they ultimately did enough to grind out a positive result and have subsequently moved to within six points of the Premier League's top four after Liverpool, Arsenal, Aston Villa and Brighton & Hove Albion, who all sit above them, dropped points.
A favourably-looking home clash with Luton Town is up next for the Red Devils in the top flight on Saturday, but they must first shift their focus to Wednesday's Champions League trip to Denmark where Ten Hag's men can ill-afford to drop points if they are to leapfrog Galatasaray into second place in Group A before locking horns with the Turkish giants in matchday five.
On the whole, Man United have enjoyed their previous visits to Denmark, winning seven of their last 10 European matches in the Scandinavian nation, but two defeats have taken place in their last three such away games.
Indeed, the Red Devils' recent away record in European competition leaves a little to be desired, as they have only won one of their last seven Champions League matches on the road - a 2-0 success at Villarreal in November 2021 under the tutelage of former caretaker boss Michael Carrick.
Copenhagen Champions League form:
W
W
D
D
L
L
Copenhagen form (all competitions):
L
D
W
L
W
W
Manchester United Champions League form:
L
L
W
Manchester United form (all competitions):
W
W
W
L
L
W
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Team News
Copenhagen are still having to cope without William Clem (leg), David Khocholava (knee) and Birger Meling (muscle) due to injury, while Mohamed Elyounoussi is doubtful after missing the last match with an unspecified problem.
Valdemar Lund could be involved in the matchday squad on Wednesday after recovering from injury, but he is not expected to start ahead of centre-back duo Denis Vavro and Kevin Diks.
Oscar Hojlund and Emil Hojlund, the brothers of Man United striker Rasmus Hojlund, will both be pushing to start, with the former hoping to fend off competition from Diogo Goncalves to retain his place in centre-midfield alongside Rasmus Falk and Lukas Lerager.
As for Man United, Marcus Rashford (knock) and Victor Lindelof (illness) are both minor doubts after missing the win at Fulham, while Casemiro (hamstring), Lisandro Martinez (foot), Luke Shaw (muscle), Amad Diallo (knee), Tyrell Malacia (knee) and Jadon Sancho (disciplinary) are all unavailable for selection.
Ten Hag will consider recalling centre-back Raphael Varane and the Frenchman's possible inclusion could therefore see Jonny Evans make way, while Diogo Dalot will again battle with Sergio Reguilon for a start at left-back if Aaron Wan-Bissaka continues at right-back.
Scott McTominay, Christian Eriksen and Fernandes are all expected to retain their places in midfield, while Antony is at risk of being dropped following a poor run of form and could be replaced on the right flank by Facundo Pellistri.
Copenhagen possible starting lineup:
Grabara; Ankersen, Vavro, Diks, Jelert; Lerager, Falk, Goncalves; Larsson, Claesson, Achouri
Manchester United possible starting lineup:
Onana; Wan-Bissaka, Varane, Maguire, Dalot; McTominay, Eriksen; Pellistri, Fernandes, Rashford; Hojlund
We say: Copenhagen 0-1 Manchester United
Copenhagen have looked strong on home soil in recent weeks and frustrated Bayern Munich for large spells in matchday two before ultimately losing 2-1 to the German side; nevertheless, a similar spirited display is required if they are to cause an upset against Man United.