While the Tangerines have failed to win any of their last four home matches, Boro are looking to avoid a fifth successive game without an away victory.
Match preview
After three Championship games without a win, Blackpool claimed maximum points in controversial circumstances when they secured a slender 1-0 victory away against Huddersfield Town last Sunday.
Theo Corbeanu put the Tangerines in front in the 38th minute, before the Terriers thought they had equalised in the second half when Yuta Nakayama appeared to bundle the ball over the line, but despite the host's celebrations, the referee was not informed by goal-line technology that the ball had cross the line.
Images have since shown that the whole of the ball did cross the line and the EFL have since apologised for the technology failing on the day. While Blackpool's win was evidently overshadowed, Michael Appleton and co will still be pleased to have returned to winning ways.
Blackpool, who currently sit 11th in the table with as many points, will be keen to put together a positive run of form in the coming weeks, but that could prove challenging given their recent record on home soil.
The Tangerines have lost four of their last seven league matches in front of their own fans while that have also suffered defeat in each of their last three home games against their upcoming opponents Middlesbrough.
Middlesbrough have endured an underwhelming start to the new campaign, winning only two of their first eight Championship matches, although the second of those victories came on Monday night in the Tees-Wear derby over Sunderland.
The 150th meeting between the two sides saw Riley McGree score the only goal of the game midway through the first half to help Boro secure a slender 1-0 win at the Riverside.
Chris Wilder's men have now climbed out of the relegation zone and up to 17th place, but they still have plenty of work to do if they wish to join the pack of promotion contenders as they currently sit four points behind the playoff and eight behind league leaders Sheffield United.
When Wilder took change of Middlesbrough in November last year, he managed to win two of his first three away games in the Championship, but his side have since won just two of their last 15 league matches on the road.
Boro were able to claim maximum points at Bloomfield Road last term, however, with a dramatic 93rd-minute winner from Duncan Watmore sealing all three points for the visitors, just two minutes after Blackpool had thought that they snatched a point through Shaye Lavery.
Blackpool Championship form:
Middlesbrough Championship form:
Team News
Blackpool will be without Kevin Stewart (foot), Lewis Fiorini (hamstring), Charlie Patino, Jake Beesley (both ankle) and Keshi Anderson (knee) due to injury.
Appleton may decide to stick with the 3-4-3 formation he used last weekend, with Corbeanu operating in the front three along with Ryan Yates and Ian Poveda.
Dominic Thompson is set to retain his place at left wing-back ahead of James Husband and Luke Garbutt, who are yet to start for the Tangerines this term.
As for Middlesbrough, goalkeeper Zack Steffen - on loan from Manchester City - and forward Chuba Akpom are both ruled out with knee injuries.
Centre-back Darragh Lenihan missed the last match due to a knock and he is doubtful for this weekend's contest, with Paddy McNair, Matthew Clarke and Dael Fry set to retain their places in the back three.
Watmore, Matthew Hoppe and Marcus Forss will all be pushing to start in attack after beginning on the bench against Sunderland, but Rodrigo Muniz could keep his place as the central striker.
Blackpool possible starting lineup:
Grimshaw; Ekpiteta, Williams Thirniley; Lawrence-Gabriel, Connolly, Dougall, Thompson; Poveda, Yates, Corbeanu
Middlesbrough possible starting lineup:
Roberts; McNair, Fry, Clarke; Jones, Mowatt, Howson, Crooks, Giles; McGree; Muniz
We say: Blackpool 1-2 Middlesbrough
There is little to separate these two sides at this early stage in the season, with both teams hoping to build on their most recent victories and climb closer towards the playoffs.