Both teams still await their first wins of the new season having had to settle for a share of the spoils in each of their opening two matches apiece.
Match preview
Lanus were held to a 1-1 draw by Defensa y Justicia on Friday when the sides went head-to-head at the Estadio Ciudad de Lanus.
Jorge Almiron's men took the lead six minutes shy of half time through Ignacio Malcorra but failed to hold on for all three points as Raul Loaiza restored parity midway through the second period.
While El Granate have excelled in the Copa Sudamericana, they are yet to get off and running in the league and will be looking to do so at the third time of asking.
Wednesday's hosts have won just one of their last 14 matches on the road, although none of the most recent seven has ended in defeat.
Atletico Tucuman played out an impressive goalless stalemate against River Plate in Sunday's meeting at the Estadio Antonio Vespucio Liberti.
Despite being under the cosh for the majority of the contest, Juan Manuel Azconzabal's men held firm to secure a hard-fought point in Buenos Aires.
With two points amassed from as many games this term, El Decano currently find themselves in the bottom half of the league table, but there is still plenty of time to turn things around.
Next up is the challenge of an opposing outfit who are yet to lose any of the previous 10 meetings between the sides all the way back to 2009.
Nonetheless, Wednesday's hosts will head into the clash with the wind between their sails having picked up two wins and a draw from their last three games on home turf.
Atletico Tucuman Argentine Primera Division form:
Atletico Tucuman form (all competitions):
Lanus Argentine Primera Division form:
Lanus form (all competitions):
Team News
Atletico Tucuman's Marcelo Ortiz is now eligible to feature once again after he missed his side's outing through a one-game suspension.
Carlos Lampe was handed a rare start against River Plate, and we expect the goalkeeper to retain his place in the XI off the back of a superb performance last time out.
Pedro de la Vega remains without an appearance for Lanus since the turn of the year as the 21-year-old continues to nurse a knee injury.
The away side will also be without the services of Mateo Sanabria, who is on international duty with the Argentina Under-19s at the moment.
Ignacio Malcorra has scored in each of his last two starts, and coupled with the fact that he found the back of the net in the last encounter between Wednesday's opponents, he is certainly one to keep an eye on.
Atletico Tucuman possible starting lineup:
Lampe; Risso, Capasso, Bianchi, Garay; Pereyra, Carrera, Acosta, Rius; Lotti, Menendez
Lanus possible starting lineup:
Monetti; Aguirre, Perez, Braghieri, Pasquini; Malcorra, Careaga, Belmonte, Gonzalez; Varaldo, Acosta