Having mustered just one point from four matches, the hosts a merely playing for pride, while Japan have already secured a top-two spot in Group B.
Match preview
Myanmar's hopes of reaching their first World Cup finals have already been quashed with two matches left to play in the current qualifying round.
The country ranked 163rd in the world began their qualifying campaign with a comfortable 5-1 aggregate victory in their first-round tie against Macau.
However, they have been unable to make any meaningful impression in the second stage, collecting just one point from four matches.
After suffering heavy defeats to Japan and North Korea, Myanmar finally got up and running with a 1-1 draw against Syria, before they were quickly stopped in their tracks by a demoralising 7-0 loss in the return fixture.
Having shipped 19 goals in their four matches, they currently hold the second-worst defensive record in the second phase of qualifying, and they will need to offer a dramatic improvement if they are to trouble the group leaders on Thursday.
In contrast to their hosts, Japan have already secured their place in the next round after collecting maximum points in their four qualifiers.
They flew out the blocks with consecutive 5-0 victories over Myanmar and Syria, before they recorded a narrow 1-0 victory in March's home meeting with North Korea.
The Samurai Blue were due to face North Korea again four days later, but the match was cancelled before FIFA's disciplinary committee ruled that the match had been forfeited, resulting in Japan being awarded a 3-0 win which sealed their passage to the third round.
Japan boss Hajime Moriyasu would have been pleased with his side's swift progression, especially after they experienced a frustrating quarter-final exit at the Asian Cup earlier this year.
Moriyasu will be challenging his side to wrap up top spot, with the Samurai Blue sitting five points clear of Syria with just two matches left to play in Group B.
Myanmar World Cup Qualifying - Asia form:
W
D
L
L
D
L
Japan World Cup Qualifying - Asia form:
Japan form (all competitions):
Team News
Myanmar defender Hein Phyo Win is set to serve a one-match suspension after being sent off in the heavy defeat to Syria.
Captain Maung Maung Lwin will offer the home side's main goal threat, having scored both of his country's two goals in the current round of qualifying.
As for Japan, Zion Suzuki is expected to start in goal, with Yukinari Sugawara, Ko Itakura, Takehiro Tomiyasu and Hiroki Ito all set to feature in the backline.
Liverpool midfielder Wataru Endo is likely to return to the lineup after being utilised as a substitute in Japan's most outing against North Korea in March.
Feyenoord striker Ayase Ueda will be given the responsibility of leading the line, having scored 11 goals in 25 international appearances.
Myanmar possible starting lineup:
Phyo; K H Paing, P W Hein, Kyaw, Soe; T Aung, L W Aung, Nay, L M Aung, K K Z Hein; Lwin
Japan possible starting lineup:
Suzuki; Sugawara, Itakura, Tomiyasu, Ito; Endo, Morita; Doan, Minamino, Maeda; Ueda