The Blades are on the brink of relegation owing to their 4-1 loss to Burnley at the weekend, while the Red Devils survived a calamitous collapse against Coventry City in the FA Cup semis, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. SHEFFIELD UNITED
MANCHESTER UNITED
Out: Willy Kambwala (unspecified), Mason Mount (unspecified), Sofyan Amrabat (unspecified), Jonny Evans (muscle), Raphael Varane (muscle), Lisandro Martinez (calf), Victor Lindelof (hamstring), Luke Shaw (thigh), Tyrell Malacia (muscle), Anthony Martial (groin)
Doubtful: Scott McTominay (groin), Harry Maguire (groin), Marcus Rashford (unspecified)
Sports Mole's predicted XI: Onana; Dalot, Casemiro, Maguire, Wan-Bissaka; Mainoo, Eriksen; Antony, Fernandes, Garnacho; Hojlund
SHEFFIELD UNITED
Out: Jack Robinson (ankle), Tom Davies (thigh), George Baldock (calf), Daniel Jebbison (illness), John Egan (ankle), Chris Basham (ankle), Rhys Norrington-Davies (thigh), Max Lowe (ankle)
Doubtful: Rhian Brewster (thigh)
Sports Mole's predicted XI: Grbic; Ahmedhodzic, Holgate, Trusty; Bogle, Souza, McAtee, Arblaster, Osborn; Brereton Diaz, Archer
For data analysis of the most likely results, scorelines and more for this match please click here.