This will be Ruud van Nistelrooy's first and final European game in interim charge of the Red Devils, as Ruben Amorim will arrive to take over after November's international break.
The Man United caretaker has seen results steadily go in the right direction, beating Leicester City to reach the EFL Cup quarter-finals, before drawing 1-1 with Chelsea on Sunday.
Here, Sports Mole rounds up Man United's injury and suspension news ahead of their contest with PAOK, who are the reigning Greek champions, and sit second in the Super League after 10 games, but are winless in this competition.
Leny Yoro
Status: Out
Type of injury: Foot
Possible return date: December 3 (vs. Arsenal)
Yoro will remain sidelined for at least another month, as the summer signing continues his recovery from the fractured metatarsal he suffered in the pre-season friendly with Arsenal back in July.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia's injury worries have often been shrouded in mystery, but after missing the entirety of last season, the Dutchman is closing in on a comeback after recently returning to training.
Luke Shaw
Status: Out
Type of injury: Calf
Possible return date: Unknown
Shaw has been missing since featuring in the Euro 2024 final for England, and just as it seemed as though he was closing in on a return, the left-back suffered yet another setback in his recovery recently.
Kobbie Mainoo
Status: Out
Type of injury: Muscle
Possible return date: November 10 (vs. Leicester)
While a return for Mainoo in this one seems unlikely, Van Nistelrooy could hold him back until after the international break to optimise his recovery time from a muscular problem, but he is in contention to face Leicester at the weekend.
Mason Mount
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Mount has been missing since he was forced off after a nasty head collision in the defeat at home to Tottenham Hotspur at the end of September, but the reasons for his continued absence are currently unclear, with the ex-Chelsea man still not back in training.
Antony
Status: Out
Type of injury: Ankle
Possible return date: Unknown
After being stretchered off the field in the Europa League clash away to Fenerbahce two weeks ago, Antony has missed the last three against West Ham United, Leicester and Chelsea, with the Brazilian expected to remain on the sidelines.
Harry Maguire
Status: Out
Type of injury: Muscle
Possible return date: November 10 (vs. Leicester)
Maguire is currently out with a muscular problem meaning that a call up to the England squad in November appears unlikely, even if he is able to return at the weekend against his former club Leicester, but the defender is a major doubt for that one.
MANCHESTER UNITED'S SUSPENSION LIST
Man United have no players suspended for this Europa League clash.