With United struggling for a top-eight finish in the Premier League table, Ruben Amorim is expected to name a strong side for the meeting at Old Trafford.
Although the Red Devils head into this contest having only lost two of their eight matches during 2025, they succumbed to defeat at home to Crystal Palace on Sunday.
Here, Sports Mole rounds up Man United's injury and suspension news ahead of their contest with Leicester as they again welcome back club legend Ruud van Nistelrooy.
Luke Shaw
Status: Major doubt
Type of injury: Hamstring
Possible return date: February 7 (vs. Leicester)
Having been absent since the start of December with a hamstring injury, Shaw is back in training. However, Amorim has given every indication that he has no plans to rush the England international back, the likelihood being that this game will come too soon.
Mason Mount
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Mount has remained out with a hamstring injury since the middle of December and the playmaker will not return until the back end of February at the earliest.
Jonny Evans
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Veteran Evans is unavailable for selection because of a muscular problem, and he is set to be missing once again on Friday.
Lisandro Martinez
Status: Out
Type of injury: Knee
Possible return date: Unknown
United were dealt a significant blow on Sunday when Martinez suffered a serious knee injury against Palace. It has since been confirmed that the Argentina international will miss the rest of the season.
MANCHESTER UNITED'S SUSPENSION LIST
Man United have no players suspended for the tie with the Foxes.
Written by
Darren Plant