The Blues recorded a 2-1 victory over Newcastle United in the league last weekend, but they were then beaten 2-0 by the same opposition in the EFL Cup on Wednesday night.
Enzo Maresca's side have performed above expectations in England's top flight during the 2024-25 campaign, with a total of 17 points from nine matches leaving them in fifth position in the Premier League table.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their trip to Old Trafford.
Omari Kellyman
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Kellyman has struggled with fitness issues since joining the Blues from Aston Villa in the summer; the attacker remains on the sidelines for this match due to a hamstring problem, and it is unclear when he will be able to return.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues heading into this contest, but Jadon Sancho will not be able to face his parent club, with the attacker ineligible, as he is currently on loan at the Blues from Man United.
Paris Saint Germain 
Arsenal 
Bodo/Glimt 
Tottenham 
Manchester Utd 
Athletic Bilbao 
Chelsea 
Djurgarden 
Fiorentina 
Betis 
Zorya Luhansk 
Shakhtar Donetsk 
Polissya Zhytomyr 
Dynamo Kyiv 
Bordeaux 
VFL Wolfsburg 
1899 Hoffenheim 
Sampdoria 
Salernitana 
AC Milan 
Bologna 
Valencia 
Getafe 
Werder Bremen 
RB Leipzig 
Fulham 
Everton 
Southampton 
Manchester City 
Celtic 
Hibernian 
Celta Vigo 
Sevilla 
Granville US 
Lazio 
Juventus 
Bayern Munich 
Borussia Monchengladbach 
CSKA Moscow 
Krasnodar 
Amiens 
Benfica 
Sporting CP 
Atletico Madrid 
Real Sociedad 
LE Havre 
Marseille 
Monaco 
Lyon 
Montpellier 
Udinese 
Monza 
Newcastle 
Rangers 
Aberdeen