The Blues recorded a 2-1 victory over Newcastle United in the league last weekend, but they were then beaten 2-0 by the same opposition in the EFL Cup on Wednesday night.
Enzo Maresca's side have performed above expectations in England's top flight during the 2024-25 campaign, with a total of 17 points from nine matches leaving them in fifth position in the Premier League table.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their trip to Old Trafford.
Omari Kellyman
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Kellyman has struggled with fitness issues since joining the Blues from Aston Villa in the summer; the attacker remains on the sidelines for this match due to a hamstring problem, and it is unclear when he will be able to return.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues heading into this contest, but Jadon Sancho will not be able to face his parent club, with the attacker ineligible, as he is currently on loan at the Blues from Man United.