Ange Postecoglou's side produced the upset of the last 16 in the EFL Cup on Wednesday, besting Manchester City 2-1 to set up a quarter-final showdown with their bitter rivals Manchester United.
That shock success versus Pep Guardiola's side was the perfect response to a chastening 1-0 defeat at Crystal Palace last weekend, a result that left Spurs in a mediocre eighth place in the Premier League table.
Here, Sports Mole wraps up the latest injury and suspension news for Spurs ahead of the visit of Villa, who were eliminated from the EFL Cup with a 2-1 home loss to Crystal Palace in midweek.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Micky van de Ven was inconsolable as he came off with another hamstring injury in the win over Man City, as he memorably spent weeks out with a similar issue last season. The severity of his issue has not yet been determined, but he will definitely miss out here.
Son Heung-min
Status: Major doubt
Type of injury: Thigh
Possible return date: November 3 (vs. Aston Villa)
Son Heung-min was not risked for the visit of Man City due to his own thigh complaint, but Postecoglou is crossing his fingers that his captain will be fit and firing this weekend.
Djed Spence
Status: Major doubt
Type of injury: Groin
Possible return date: November 3 (vs. Aston Villa)
Similarly, Djed Spence could be back in Spurs training this week as he steps up his recovery from a groin strain, and he will push to make the matchday squad on Saturday.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Wilson Odobert had just recovered from one hamstring problem before being struck by a "serious" setback in the same area, and the ex-Burnley man is set for another spell on the sidelines.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for this match.