Erik ten Hag's side will enter the match off the back of a 4-2 victory over Sheffield United on Wednesday evening, with the Red Devils twice coming from behind to pick up a much-needed three points.
The 20-time English champions returned to sixth position in the table courtesy of their triumph and Newcastle United's loss at Crystal Palace, but they are still 13 points off fourth-placed Aston Villa.
Here, Sports Mole rounds up Man United's latest injury and suspension news ahead of the clash with Burnley, who are 19th in the table, three points from the safety of 17th spot.
Raphael Varane
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Varane was forced off at the interval of the recent clash with Chelsea due to another injury problem, and it has been revealed that a muscular issue will keep him out until the latter stages of the season.
Jonny Evans
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Evans has struggled with a number of muscular issues in recent weeks, and the experienced centre-back remains on the sidelines for the game against Burnley.
Victor Lindelof
Status: Out
Type of injury: Hamstring
Possible return date: May 6 (vs. Crystal Palace)
Lindelof will again be absent due to the hamstring issue which he picked up in the recent Premier League contest with Brentford, but he could be back at the start of May.
Lisandro Martinez
Status: Out
Type of injury: Calf
Possible return date: May 6 (vs. Crystal Palace)
Martinez picked up a calf issue during a training session earlier this month, but the Argentina international has a chance of returning to action against Palace on May 6.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia is back in individual training, as he bids to recover from a knee injury which has required two separate operations, but the Dutchman is set to miss the rest of the season.
Anthony Martial
Status: Out
Type of injury: Groin
Possible return date: Unknown
Martial underwent a groin operation in January; he is back in individual training but might have played his last game for the club, with the forward's contract set to expire at the end of June.
Luke Shaw
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Shaw is currently on the sidelines with another muscular problem, but the left-back is believed to be on course to return to action before the season ends.
Willy Kambwala
Status: Out
Type of injury: Unknown
Possible return date: Unknown
Kambwala has missed Man United's last two matches with an unspecified issue, and he will again be absent for the 20-time English champions on Saturday afternoon.
Mason Mount
Status: Minor doubt
Type of injury: Unknown
Possible return date: April 27 (vs. Burnley)
Mount has been absent for Man United's last two games against Coventry City and Sheffield United, but the playmaker is expected to be back in the squad on Saturday afternoon.
Marcus Rashford
Status: Major doubt
Type of injury: Unknown
Possible return date: April 27 (vs. Burnley)
Rashford did not feature against Sheffield United due to a problem which he picked up against Coventry, but the attacker has a slight chance of being back in the squad for this game.
MANCHESTER UNITED SUSPENSION LIST
Man United have no players suspended for this match.