The Red Devils have endured their worst-ever start to a Premier League season, winning just two of their opening seven matches and collecting only eight points, leaving Erik ten Hag's side languishing in 14th place in the table.
Man United drew 0-0 with Aston Villa prior to the international break, while Brentford beat Wolverhampton Wanderers 5-3 last time out and are two points better off than the Red Devils, sitting 11th in the top-flight standings.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 19
Man Utd wins: 10
Draws: 3
Brentford wins: 6
Man United and Brentford have butted heads a total of 19 times across all competitions, with the Red Devils leading the head-to-head record having posted 10 wins to the Bees' six, while there have also been three draws played out between these two teams.
January 1928 was the first time that Man United and Brentford faced off in an FA Cup third-round tie, with the former securing a thumping 7-1 victory at Old Trafford thanks to four goals scored by James Hanson.
Man United also won their first-ever league meeting with Brentford in 1933, a 4-3 triumph away from home in the old Division Two, but the Bees got their revenge and won the reverse fixture 3-1 - the first of five victories in six matches against the Red Devils across all competitions over a five-year period.
Since Brentford secured promotion to the Premier League for the first time in 2022, Man United have faced the Bees six times, winning four of those and scoring nine goals in the process.
Ralf Rangnick's Man United beat Brentford 3-1 away from home in January 2022 before completing the double over the Bees courtesy of a 3-0 win at Old Trafford four months later - Cristiano Ronaldo and Bruno Fernandes were on the scoresheet in that fixture.
Ten Hag's first encounter with Brentford was certainly one to forget, as his Man United side suffered a heavy 4-0 defeat at the Gtech Community Stadium in August 2022, with Josh Dasilva, Mathias Jensen, Ben Mee and Bryan Mbeumo all scoring inside the opening 35 minutes.
Man United came out on top by a narrow 1-0 scoreline in the reverse fixture, though, thanks to a first-half strike from Marcus Rashford, and they also beat Thomas Frank's side 2-1 on home soil the following season when Scott McTominay scored two dramatic stoppage-time goals to snatch maximum points.
The most recent meeting between these two teams took place at the Gtech Community Stadium in March 2024 when Mason Mount's 96th-minute strike was cancelled out by a 99th-minute equaliser from Kristoffer Ajer in a pulsating 1-1 draw.
Last six Premier League meetings
Mar 30, 2024: Brentford 1-1 Man Utd (Premier League)
Oct 07, 2023: Man Utd 2-1 Brentford (Premier League)
Apr 05, 2023: Man Utd 1-0 Brentford (Premier League)
Aug 13, 2022: Brentford 4-0 Man Utd (Premier League)
May 02, 2022: Man Utd 3-0 Brentford (Premier League)
Jan 19, 2022: Brentford 1-3 Man Utd (Premier League)
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