Man Utd0 - 0FC Twente

The Uruguay international will feature alongside Christian Eriksen in the middle of midfield, with Kobbie Mainoo dropping down to the bench for the 20-time English champions.

There are two further changes from the side that started the goalless draw with Crystal Palace in the Premier League on Saturday.

Harry Maguire is introduced at the back, with Matthijs de Ligt dropping to the bench, while Marcus Rashford returns to the side in place of Alejandro Garnacho.

Rasmus Hojlund made his first appearance of the season off the bench against Palace, having recovered from a hamstring problem, but Joshua Zirkzee continues through the middle.

As for Twente, their main threat will likely come from Sem Steijn, who has scored seven times and registered one assist in eight appearances at club level this term.

There is also a spot in the final third of the field for Sam Lammers, who has three goals this term, while Ricky van Wolfswinkel, formerly of Norwich City, starts for the visitors to Old Trafford.

Manchester United: Onana; Mazraoui, Maguire, Martinez, Dalot; Ugarte, Eriksen; Amad, Fernandes, Rashford; Zirkzee

Subs: Bayindir, Heaton, De Ligt, Evans, Casemiro, Collyer, Mainoo, Mount, Antony, Garnacho, Hojlund

FC Twente: Unnerstall; Van Rooij, Hilgers, Bruns, Salah-Eddine; Regeer, Vlap; Steijn; Van Wolfswinkel, Lammers, Van Bergen

Subs: El Maach, Tyton, Lagerbielke, Kjolo, Kuipers, Eiting, D Rots, Van Hoorenbeeck, Mesbahi, Ltaief, M Rots, Besselink