As a result of their Champions League quarter-final exit, City will have had six days to prepare for this contest on the back of their 2-0 victory at Nottingham Forest last weekend.
Although Arsenal are playing in the early kickoff on Saturday and could potentially go four points clear in the standings, Pep Guardiola's side continue to have their fate in their own hands heading into this contest.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of hosting Wolves, who prevailed in the reverse fixture back in September.
Phil Foden
Status: Minor doubt
Type of injury: Illness
Possible return date: May 4 (vs. Wolves)
Phil Foden was a surprise absentee for the Forest game due to illness. However, the expectation is that the playmaker will be back in the squad, potentially the starting lineup for this contest.
Ruben Dias
Status: Minor doubt
Type of injury: Illness
Possible return date: May 4 (vs. Wolves)
Like Foden, Ruben Dias has been ill in recent days, but Guardiola indicated that the "fever" that the centre-back was dealing with was more severe than what Foden had. While Dias could return to the squad, it remains to be seen whether he would feature in the starting lineup.
Ederson
Status: Out
Type of injury: Shoulder
Possible return date: Unknown
Goalkeeper Ederson suffered a shoulder injury in a collision with Nottingham Forest defender Willy Boly. Guardiola indicated after the game that the issue "does not look good" and the Brazilian may be in a battle to return before the end of the season.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no suspended players for this match.