The Citizens, who lost each of their last four games prior to the international break, have received a welcome injury boost this week as Jack Grealish, Kevin De Bruyne, John Stones and Manuel Akanji have all taken part in training along with Phil Foden.
Ruben Dias has spent time in Lisbon working on his recovery from a calf problem and he along with Jeremy Doku (muscle), Nathan Ake (fitness) and Matheus Nunes (unspecified) will all be assessed ahead of kickoff. Rodri (ACL) and Oscar Bobb (leg fracture) remain long-term absentees, though.
Pep Guardiola, who has allegedly agreed to sign a one-year contract extension at the Etihad, handed a Jahmai Simpson-Pusey his Premier League debut in a 2-1 defeat at Brighton last time out, but the 19-year-old could be replaced in central defence by one of Stones, Akanji or Dias if they are deemed fit to start.
Josko Gvardiol was also handed a start at centre-back against Brighton, but he will likely move over to left-back as Rico Lewis and ex-Spurs man Kyle Walker - who both represented England last week - battle for a start at right-back.
Having now retired from international football with Germany, a well-rested Ilkay Gundogan is in contention to start in centre-midfield alongside Mateo Kovacic, while Guardiola will weigh up whether to start one, or even both, of Foden and De Bruyne in advanced roles.
Bernardo Silva could operate out wide if he is not deployed centrally, while Savinho and Erling Haaland - the latter scored four goals in two games for Norway over the international break - are both set to start in the final third.
Manchester City possible starting lineup: Ederson; Walker, Stones, Akanji, Gvardiol; Kovacic, Gundogan; Bernardo, Foden, Savinho; Haaland