The Red Devils have been beaten in their last two league games against Arsenal and Nottingham Forest, which has left them down in 13th spot in the Premier League table.
However, Ruben Amorim's side will enter this match off the back of a positive result, having come from behind to beat Viktoria Plzen in the Europa League on Thursday night.
Here, Sports Mole rounds up Man United's injury and suspension news ahead of their contest with Man City, who have only won one of their last 10 games in all competitions during a hugely difficult period.
Jonny Evans
Status: Minor doubt
Type of injury: Unspecified
Possible return date: December 15 (vs. Manchester City)
Evans was again not in the squad against Plzen on Thursday night, but the centre-back is back in training, and it is thought that he will be available for selection this weekend if required.
Luke Shaw
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Shaw has only just worked his way back from a calf issue, but the England international has now picked up a hamstring problem and is set to be sidelined for several weeks; the defender has opened up on his devastation at his ongoing injury issues, but Amorim has promised to continue backing him.
MANCHESTER UNITED'S SUSPENSION LIST
Man United have no players suspended for the Premier League clash.
Written by
Matt Law