The Citizens head into this Premier League showdown having won just one of their last 10 matches in all competitions, losing seven of those including a 2-0 Champions League defeat to Juventus on Wednesday.
Pep Guardiola's men now shift their focus back to domestic duties and currently sit fourth in the Premier League table, eight points behind leaders Liverpool having played a game more than the Merseysiders.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Ruben Amorim's side.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Man City are set to be without influential midfielder Rodri for the rest of the season after he suffered knee ligament damage in a 2-2 draw with Arsenal in September.
However, the Spaniard has since offered a positive update on hia recovery and has set a new target for when he wishes to return.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb sustained a fracture to a bone in his leg during a training session in August and Guardiola has revealed that the attacker is targeting a return between January and February of next year.
John Stones
Status: Out
Type of injury: Foot
Possible return date: Unknown
John Stones has missed Man City's last five games since coming off at half time in last month's 4-0 defeat to Spurs with a foot injury, and there is currently no timeframe on the defender's return.
Nathan Ake
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Nathan Ake sustained a hamstring injury in the closing stages of Man City's win over Nottingham Forest on December 4, and Guardiola has since revealed that the injury-prone defender is facing another spell on the sidelines.
Manuel Akanji
Status: Major doubt
Type of injury: Unspecified
Possible return date: December 15 (vs. Man United)
Manuel Akanji was taken off at half time against Nottingham Forest with an unspecified problem. Guardiola stated after the match that the defender has "struggled a lot over the last two months" with the issue, and as things stand, he is a major doubt for Sunday's match.
Mateo Kovacic
Status: Minor doubt
Type of injury: Unspecified
Possible return date: December 15 (vs. Man United)
Mateo Kovacic sustained an unspecified injury on international duty with Croatia last month, but he returned to the matchday squad against Juventus in midweek and should be fit to feature against Man United.
Phil Foden
Status: Minor doubt
Type of issue: Fitness
Possible return date: December 15 (vs. Man United)
Phil Foden missed two of Man City's matches due to bronchitis before watching on as an unused substitute in the midweek defeat to Juventus. The 24-year-old has returned to training and should be fit to feature on Sunday, with Guardiola set to provide an update on his fitness at a press conference on Friday.
MANCHESTER CITY'S SUSPENSION LIST
Rico Lewis
Return date: December 21 (vs. Aston Villa)
Rico Lewis will serve a one-match suspension on Sunday after he was sent off for two bookable offences in Man City's 2-2 draw with Crystal Palace last weekend.
Written by
Oliver Thomas