Los Blancos were denied three points in the Madrid derby late on at the weekend, conceding a stoppage-time equaliser, and will look to return to winning ways here after victory on matchday one against Stuttgart.
Lille will come into the game confident after a comfortable 3-0 win over Le Havre on Saturday, and based on the fact they have won seven of their previous eight home games in Europe.
Here, Sports Mole rounds up Real Madrid's injury and suspension news ahead of their trip to Lille on matchday two.
David Alaba
Status: Out
Type of injury: Knee
Possible return date: Unknown
David Alaba suffered an ACL injury last December, which has required him to undergo two operations so far, and no date has been put in place for when he may return to the fold.
Thibaut Courtois
Status: Minor doubt
Type of injury: Muscle
Possible return date: October 2 (vs. Lille)
Goalkeeper Thibaut Courtois was the centre of attention at the Metropolitano against Atletico Madrid, but after conceding a late equaliser, manager Carlo Ancelotti also confirmed that the Belgian suffered a muscle injury during the match, and will undergo a late fitness to see if he can feature in Northern France.
Dani Ceballos
Status: Out
Type of injury: Ankle
Possible return date: October 19 (vs. Celta Vigo)
Dani Ceballos is currently sidelined due to an ankle injury he suffered during Real Madrid's clash with Real Betis on the first day of September, and the midfielder is being pencilled in for a return shortly after the upcoming October international break.
Brahim Diaz
Status: Out
Type of injury: Abductor
Possible return date: Unknown
Brahim Diaz will not return until late in the year because of a hip abductor injury that he suffered against Real Sociedad midway through September.
Kylian Mbappe
Status: Out
Type of injury: Thigh
Possible return date: October 19 (vs. Celta Vigo)
Real Madrid will be without Kylian Mbappe until after the October international break due to the thigh injury that he picked up in the 3-2 win over Alaves last week.
Fran Garcia
Status: Major doubt
Type of injury: Achilles tendon
Possible return date: October 2 (vs. Lille)
Fran Garcia was on the receiving end of a horror challenge by Marcos Llorente in the final minute of the Madrid derby on Sunday, and Ancelotti has confirmed he will undergo tests regarding an Achilles tendon injury suffered in that tackle.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for their clash with Lille.