The hosts are six points adrift of safety, while the visitors are two points above the relegation zone with four games remaining.
Match preview
Kayserispor ended their six-game winless run with a 2-1 victory over relegation-threatened Pendikspor at Pendik Stadium last Sunday.
After falling behind in the seventh minute, the Anatolian Stars equalised through Aylton Boa Morte in first-half stoppage time, before eventually securing the win courtesy of Mehdi Bourabia's 56th-minute goal.
The win saw Burak Yilmaz's side climb to 12th in the table, having picked up 40 points from 34 matches, and boosted their chances of survival.
Kayserispor host Fatih Karagumruk on Saturday, looking to pull further away from the relegation zone. However, their record against the visitors is poor, having lost their last four meetings by a combined scoreline of 13-3.
Their home form is also a concern heading into this clash, having won just one of their last nine games at Kadir Has Stadium. With the league reaching its climax, picking up points from any source will be crucial for the Anatolian Stars to confirm their top-flight status for another season.
Fatih Karagumruk have found form at the right time, picking up a second consecutive victory with a convincing 4-1 win over ten-man Antalyaspor last time out.
The victory lifted the Kara Kirmizis out of the relegation zone, as they now sit in 15th place with 36 points from 34 games, two points clear of 17th-placed Gaziantep.
The Istanbul side will hope to maintain this momentum until the end of the season to secure their survival. However, their away form has been a weakness this campaign.
Karagumruk are the third-worst team on the road, with just nine points from a possible 51 away from home. However, they won on their last visit to Kayseri and will be hoping to repeat the feat at this crucial stage of the season.
Kayserispor Turkish Super Lig form:
D
L
L
D
L
W
Fatih Karagumruk Turkish Super Lig form:
L
D
L
L
W
W
Fatih Karagumruk form (all competitions):
D
D
L
L
W
W
Team News
The hosts will be without Bourabia who was sent off in the win over Pendikspor and is suspended for one match.
They are also expected to remain without Anthony Uzodimma and Majid Hosseini who are currently nursing long-term injuries, with neither expected back in the near future.
Lionel Carole and Julian Jeanvier are both battling knee injuries, while Ali Karimi is out of the season with a ligament issue.
The visitors have a fully fit squad for this clash, with no injuries or suspensions reported.
Marcao is expected to lead the line once again after finding the net last time out, while Valentin Eysseric will provide support behind the striker.
Kayserispor possible starting lineup:
Bayazit; Kaldirim, Kolovetsios, Kocaman, Sazdagi; Yilmaz; Shukurov, Civelek, Boa Morte, Cardoso; Nazon
Fatih Karagumruk possible starting lineup:
Sirigu; Veseli, Biraschi, Ceccherini, Mercan; Rohden, Feghouli; Yalcin, Eysseric, Keles; Marcao