The season's first Milan derby comes after Inter stubbornly defied Manchester City last time out, when Simone Inzaghi made an unexpected change in attack.
After his side were held to a 1-1 draw by Monza, captain Lautaro Martinez was surprisingly dropped to the bench in Manchester, with summer signing Mehdi Taremi starting instead.
Last term's Capocannoniere, 'El Toro' has yet to score a goal this season, but he has found the net eight times against Milan to date and will most likely be recalled to the starting XI.
Federico Dimarco should also return, replacing Carlos Augusto on the Nerazzurri's left flank, having been ruled out by a minor muscular injury in midweek.
Two more key cogs in last season's title-winning machine, Benjamin Pavard and Henrikh Mkhitaryan, are pushing for starts, too. Both appeared from the bench on Wednesday evening, and they could now displace Yann Bisseck and Piotr Zielinski respectively.
In-form forward Marcus Thuram will definitely start up front, having scored four goals in as many league games so far, partnering Martinez at the tip of Inzaghi's trademark 3-5-2 formation.
With Dimarco back in the fold, Inzaghi's only absentee is Canadian wing-back Tajon Buchanan, who will be out of action until December.
Inter Milan possible starting lineup: Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Martinez