Martino oversaw a successful regular season which saw Inter Miami win the Supporters' Shield for the first time in their history.
Inter Miami also broke the MLS record for the most points in a single season, with Martino's side collecting 74 points from 34 matches.
Unfortunately for Martino, his star-studded team were unable to produce the same sort of dominance in the MLS playoffs.
Inter Miami were stunned by Atlanta United in the first round of the playoffs, losing a three-match series by a 2-1 scoreline despite winning the first game.
Martino to leave Inter Miami
There have been rumours surrounding Martino's future since Inter Miami lost 3-2 to Atalanta in the decisive match of the series earlier this month.
According to ESPN, Martino has now taken the decision to leave his post as Inter Miami head coach due to personal reasons.
Martino is expected to address the media at a news conference on Friday along with co-owner Jorge Mas and president of football operations Raul Sanllehi.
The 61-year-old became the third permanent head coach in Inter Miami's history when he succeeded Phil Neville in June 2023.
As well as winning the Supporters' Shield this year, Martino guided the club to Leagues Cup glory and a US Open Cup final in 2023.
Martino is set to leave Inter Miami after winning 38, drawing 13 and losing 16 of his 67 competitive matches in charge.
Messi's sense of Deja vu
Lionel Messi is set to bid farewell to Martino for the third time in his career after previously playing under him at Barcelona and Argentina.
Martino left Barcelona in 2014 after just one season with the Catalan giants, before he resigned from his post as Argentina boss in 2016 following a two-year spell in charge.
It now remains to be seen who replaces Martino and how much of an influence Messi will have on the identity of the new manager.
The chosen candidate will have to contend with a busy 2025 schedule which includes an appearance at the expanded Club World Cup.