La Roja needed extra-time to progress from their clash with Croatia, and the likes of Dani Olmo and Mikel Oyarzabal played key roles for the three-time European champions off the bench.
Enrique is likely to select the same XI that started on Monday, though, meaning that there could be frustration for Marcos Llorente and Pau Torres, who were in the side at the start of the tournament.
Cesar Azpilicueta and Eric Garcia should retain their spots at the back, while there are unlikely to be any alterations in the middle of the park, with Pedri lining up alongside Koke and Sergio Busquets.
There are a whole host of options in the final third, with Oyarzabal and Olmo pushing for starts, while Gerard Moreno will also be hoping to impress before the tournament finishes.
Ferran Torres and Pablo Sarabia were both excellent against Croatia, though, and should retain their positions alongside Alvaro Morata, who has the full support of his manager.
Morata scored a brilliant extra-time goal against Croatia, and a 4-3-3 formation will see him line up as the centre-forward once again.
Spain possible starting lineup: Simon; Azpilicueta, Garcia, Laporte, Alba; Koke, Busquets, Pedri; Sarabia, Morata, F Torres