La Roja will enter this weekend's contest off the back of a 2-1 defeat to Sweden on Thursday, which saw the Euro 2020 semi-finalists drop into second position in Group B.
David de Gea, who has impressed for Manchester United in the early stages of the season, could be in line for a spot between the sticks, while Marcos Llorente, Raul Albiol and Jose Gaya may come into the back four.
Carlos Soler and Koke are likely to retain their midfield spots, but Rodri could replace Sergio Busquets, while Enrique is also expected to shuffle his pack in the final third of the field.
Ferran Torres started wide against Sweden but has been excellent through the middle for Manchester City this season, and the 21-year-old could feature in that area of the field for this match.
Pablo Sarabia and Brais Mendez are pushing to be involved in the wide areas, while Adama Traore will also be hoping to earn some more minutes, likely off the bench.
Gerard Moreno and Alvaro Morata both found it difficult to impress on Thursday evening and could now drop down to the bench for Spain's fourth fixture in Group B.
Spain possible starting lineup: De Gea; Llorente, Albiol, Laporte, Gaya; Soler, Rodri, Koke; Mendez, F Torres, Sarabia