La Roja booked their spot in the round of 16 courtesy of a 5-0 success over Slovakia in their final Group E match on Wednesday, and the performance would have given Enrique plenty to digest.
Pablo Sarabia was excellent in the five-goal victory and should retain his spot in the final third, while Alvaro Morata seemingly has the full support of his manager and is likely to keep his position at centre-forward despite missing a penalty last time out.
Cesar Azpilicueta's performance could also see the Chelsea defender keep out Marcos Llorente, but there is expected to be a change at the back, with Pau Torres likely to replace Eric Garcia in the middle.
Enrique has plenty of options in the middle of the park, but it would not be a surprise to see Koke, Sergio Busquets and Pedri line up as the central three once again.
It would be fair to say that the Spain manager has not settled on his first-choice wide attackers, with Ferran Torres struggling to make his mark in the first two matches at Euro 2020, which opened the door for Sarabia to claim a spot.
Morata, as mentioned, is expected to retain his position, and there could be another start for Gerard Moreno, but there is pressure from the likes of Mikel Oyarzabal and Dani Olmo, who are also both in contention.
Spain possible starting lineup: Simon; Azpilicueta, Laporte, Torres, Alba; Pedri, Busquets, Koke; Sarabia, Morata, G Moreno