The European outsiders lost Angel Montoro to a suspected hamstring issue after just 13 minutes against Real Betis on Monday, while Yangel Herrera (quadriceps) and Domingos Duarte (knee) had to be withdrawn later on in the game.
Granada have been plagued by injuries all season, and the trio join the unfortunate quintet of Kenedy, Carlos Neva, Jesus Vallejo, Luis Milla and Neyder Lozano in the infirmary.
Fede Vico replaced Montoro in the number 10 role on Monday night and should do so from the first whistle here, while Yan Eteki and Nehuen Perez are expected to fill in for Herrera and Duarte, assuming they both miss out as expected.
Roberto Soldado will serve the second of a three-game ban following his sending off against Cadiz, so Luis Suarez should fend off competition from Jorge Molina to start up front.
Darwin Machis's consolation goal will likely see him keep his spot on the left over Alberto Soro, but Martinez has plenty of options for change in the full-back positions, with Victor Diaz and Adrian Marin both waiting in the wings.
Granada possible starting lineup: Escandell; Foulquier, Perez, Sanchez, Quini; Eteki, Gonalons; Puertas, Vico, Machis; Suarez