Alba and De Jong are both likely to be back in the starting side this weekend, but the Catalan giants still have a number of injury concerns heading into their final fixture of the campaign.
Eric Garcia, Nico Gonzalez, Sergi Roberto, Sergino Dest and Pedri all definitely out of this contest through injury, while Memphis Depay and Gerard Pique are also major doubts.
Ronald Araujo should be available following a concussion, though, with the defender set to make a timely return for the home team, potentially partnering Clement Lenglet in the middle.
Memphis's hip problem that he suffered in the goalless draw with Getafe last weekend, meanwhile, could see Ousmane Dembele come into the front three on Sunday.
Dembele's future remains the subject of much speculation, with his contract due to expire at the end of June, and a meeting will allegedly be held after the match with the Yellow Submarine.
Riqui Puig and Alejandro Balde could be the two players to drop out to allow De Jong and Alba to return, but Gavi should retain his spot in the middle of midfield.
Ansu Fati will continue his injury recovery off the bench, meanwhile, while Adama Traore will also be hoping to feature, as the Spaniard bids to earn a permanent move from Wolverhampton Wanderers.
Barcelona possible starting lineup: Ter Stegen; Alves, Araujo, Lenglet, Alba; Gavi, Busquets, F de Jong; Dembele, Aubameyang, Torres