That should see experienced centre-back Nicolas Otamendi return to the starting XI alongside young Ajax star Lisandro Martinez, who excelled last time out in their victory, proving himself as a capable defender on the international stage.
Aston Villa goalkeeper Emiliano Martinez will also come back into the XI as well as talented left-back Marcos Acuna, having been two of the most important players in the first three games of the group stage.
Further forward, Lionel Messi will continue to be the key man in the attacking line, having hit three goals and two assists in four games in the group stage to take his tally to 75 international goals.
He should continue to support front man Sergio Aguero, who has led the line in the last two games after a slow start to the tournament.
Alejandro Gomez and Lautaro Martinez could make up the rest of the front line, having both scored in the win over Bolivia, while they will face stiff competition from the likes of Angel Di Maria and Angel Correa, given Argentina's impressive squad depth.
The slight change of system to two centre-midfielders has created plenty of competition for spots in the middle, after Leandro Paredes, Rodrigo De Paul and Giovani Lo Celso all impressed in a midfield three, with one likely to miss out to accommodate another attacking spot.
Argentina possible starting lineup: E Martinez; Molina, Otamendi, Lisandro Martinez, Acuna; Paredes, Lo Celso; Lautaro Martinez, Messi, Gomez; Aguero