Head coach Lionel Scaloni will want to ensure that his side top Group A, but there seems no need to select the likes of Lionel Messi, Angel Di Maria and Sergio Aguero from the start.
Emiliano Martinez, Nahuel Molina and Cristian Romero could keep their spots in a defensive area, but Lisandro Martinez and Marcos Acuna are in line for positions in the back four.
In midfield, Rodrigo De Paul and Nicolas Dominguez might come in for starts alongside Leandro Paredes, which would mean a switch to a 4-3-3 formation for this match.
Joaquin Correa, Angel Correa and Lautaro Martinez could be the front three for Argentina, who have picked up seven points from their three matches at this summer's competition.
Bolivia, meanwhile, have zero points and sit at the bottom of the section, meaning that Scaloni will feel that any side that he sends onto the field should have enough to triumph.
Angel Correa and Joaquin Correa only have four international goals between them, but Inter Milan centre-forward Lautaro Martinez has an impressive record of 11 strikes in 25 caps for his country.
Argentina possible starting lineup: Emiliano Martinez; Molina, Romero, Lisandro Martinez, Acuna; De Paul, Dominguez, Paredes; A Correa, Lautaro Martinez, J Correa