Interim boss Lee Carsley announced a 26-man squad last week, but Bukayo Saka, Declan Rice, Phil Foden, Jack Grealish, Trent Alexander-Arnold, Cole Palmer, Levi Colwill and Aaron Ramsdale have now all pulled out.
The Three Lions will also be without injured quintet John Stones, Kobbie Mainoo, Harry Maguire, Luke Shaw and Eberechi Eze, while the likes of Marcus Rashford, Nick Pope and James Maddison have all been omitted.
As a result of the mass withdrawal, Carsley called up Jarrod Bowen, Jarrad Branthwaite, Valentino Livramento, James Trafford and Morgan Rogers on Monday evening, the latter of whom has earned his first senior call-up along with Taylor Harwood-Bellis and Lewis Hall.
Manchester City's Kyle Walker is not 100% fit but he is in contention to feature on Thursday, while Dominic Solanke will be assessed after jarring his knee in Tottenham Hotspur's defeat to Ipswich Town last weekend.
If Walker is not deemed fit to start, then either Livramento or Rico Lewis may play at right-back. Lewis is also in contention to play at left-back and could battle for a start with uncapped Hall.
With Jordan Pickford expected to continue between the sticks, Ezri Konsa and Marc Guehi are the most likely due to start in central defence, while Lille's Angel Gomes could be partnered by Atletico Madrid's Conor Gallagher in centre-midfield in the absence of Rice.
Jude Bellingham could also be considered for a deeper midfield role, but the Real Madrid man - who scored in England's shock 2-1 loss to Greece last month - will likely operate in the number 10 role as Anthony Gordon, Noni Madueke, Bowen and Rogers all battle for starts out wide.
Captain Harry Kane has scored 17 goals in just 16 games for Bayern Munich this season and England's all-time record goalscorer is expected to lead the line ahead of both Solanke and Ollie Watkins.
England possible starting lineup: Pickford; Walker, Konsa, Guehi, Lewis; Gomes, Gallagher; Madueke, Bellingham, Gordon; Kane
Torino 
Udinese 
Cagliari 
Fiorentina 
Juve Stabia 
Sampdoria 
Genoa 
Lazio 
Parma 
Juventus 
Tottenham 
Nottingham Forest 
Valencia 
Espanyol 
Nantes 
Paris Saint Germain 
Manchester City 
Aston Villa 
Barcelona 
Mallorca 
Bukovina Chernivtsi 
Dynamo Kyiv 
Polissya Zhytomyr 
Shakhtar Donetsk 
Arsenal 
Crystal Palace 
Inter 
AC Milan 
Benfica 
Tirsense 
Getafe 
Real Madrid 
AZ Alkmaar 
Nac Breda 
Osasuna 
Sevilla 
Twente 
PSV 
Atletico Madrid 
Rayo Vallecano 
Carrarese 
Rouen 
Bordeaux 
Nice 
Feyenoord 
Pec Zwolle 
Chelsea 
Everton 
Dundee Utd 
Celtic 
Bayer Leverkusen 
FC Augsburg 
Bayern Munich 
FSV Mainz 05 
1899 Hoffenheim 
Borussia Dortmund 
VFL Wolfsburg 
SC Freiburg