Odysseas Vlachodimos has struggled for game time at Newcastle United this season, but he is regarded as the number one goalkeeper for his country and is expected to earn his 47th international cap against the Three Lions.
Liverpool left-back Kostas Tsimikas was absent from Greece's history 2-1 win over England at Wembley last month due to illness, but he is available for selection this time around and is set to join West Ham United's Konstantinos Mavropanos, Konstantinos Koulierakis and Lazaros Rota in the back four.
Dimitrios Kourbelis will serve a one-match suspension due to an accumulation of yellow cards, so either Petros Mantalos, Christos Zafeiris or Sotiris Alexandropoulos could deputise alongside Cardiff City's Manolis Siopis in centre-midfield.
Captain Anastasios Bakasetas scored his 16th international goal in a 2-0 win over the Republic of Ireland last time out and is expected to retain his spot in the number 10 role, while Giorgos Masouras and Christos Tzolis are the most likely duo to operate on the flanks.
Benfica's Vangelis Pavlidis scored two of his eight international goals for Greece in their away victory over England last month and he could continue up front in Ivan Jovanovic's starting lineup. However, Fotis Ioannidis - who scored three goals in Greece's opening two Nations League games - is back in the squad after recovering from injury and will be hoping to force his way back into the first XI.
Greece possible starting lineup: Vlachodimos; Rota, Mavropanos, Koulierakis, Tsimikas; Siopis, Mantalos; Masouras, Bakasetas, Tzolis; Pavlidis