The visitors, on the other hand, make the journey to Mendoza seeking to get back to winning ways having had to settle for a share of the spoils last time out.
Match preview
River Plate left it late to snatch a 2-2 draw against Lanus in Sunday's encounter at the Estadio Monumental.
After going behind to Marcelino Moreno's opener, Martin Demichelis's men responded through Miguel Borja but soon found themselves trailing to Jonathan Torres's strike before Borja levelled matters with his second of the game.
Consequently, Los Millonarios have dropped down to seventh place in the Argentine Primera Division table, three points shy of the top four.
On the menu next is the challenge of an opposing outfit who have been beaten in seven of the last nine editions of this fixture, although their two wins in that time have come in the most recent three meetings.
Since winning three straight games on the road in April, Wednesday's visitors have failed to come out on top in any of the subsequent four and will be looking to turn the tide.
Godoy Cruz were on the receiving end of a 3-0 defeat against Racing Club when the teams locked horns at Estadio Juan Domingo Peron on Saturday.
First-half goals from Adrian Martinez and Johan Carbonero left Daniel Oldra's men on the back foot after which Gabriel Rojas sealed the deal just past the hour mark.
Still stuck on no points from five matches following a three-point deduction earlier in the campaign, La Bodeguero currently sit bottom but one in the league standings.
Aiming to pick up what would be a first home win since April, Wednesday's hosts have not fared well in front of their fans and now is as good a time as any to get themselves going.
Godoy Cruz Argentine Primera Division form:
L
L
D
D
D
L
Godoy Cruz form (all tournaments):
River Plate Argentine Primera Division form:
W
W
L
W
L
D
River Plate form (all competitions):
W
W
L
D
W
D
Team News
Juan Cejas missed Godoy Cruz's last outing through injury and the midfielder is expected to sit out Wednesday's game as well.
The home side will also be without the services of Tomas Pozzo and Braian Salvareschi, who both miss out with knee injuries.
Miguel Borja came off the bench to score twice for River Plate last time out and could be rewarded with a place back in the starting XI here.
Thirty-one-year-old Gonzalo Martinez remains a guaranteed absentee for the away side here having failed to feature since December.
Godoy Cruz possible starting lineup:
Petroli; Luciano, Rasmussen, Barrios, Arce; Poggi, Leyes, Fernandez; Barrea, Pino, Altamira
River Plate possible starting lineup:
Ledesma; Simon, Gattoni, P. Diaz, E. Diaz; Biafore, Aliendro, Mastantuono, Lanzini; Solari, Borja