The Danish defender was banned for last weekend's 1-1 draw with Everton on account of his red card in the 3-1 loss to Aston Villa two weeks prior, and he helplessly watched on as Beto levelled the scores deep into injury time.
Frank is also expecting Timothy Castagne to be available following a hamstring concern - the same goes for Andreas Pereira (knock) - but Sasa Lukic (shoulder) will not play again this side of the international break.
Andersen's return from the naughty step could bring Issa Diop's stint in the starting XI to an end, as the former Crystal Palace defender joins forces with Calvin Bassey in front of number one Bernd Leno.
Castagne's return to fitness may spell trouble for Kenny Tete, but the latter should continue to bomb down the right flank for now as Antonee Robinson takes his usual spot on the opposite side.
As Pereira has seemingly recovered from the blow he suffered at Goodison Park, the Brazilian - who has not seen any of his 26 key passes lead to a goal so far this season - will link arms with Sander Berge in the centre as ever.
Emile Smith Rowe operates just ahead of the duo, acting as another creative hub to the frontline of Alex Iwobi, Adama Traore and Raul Jimenez, although Reiss Nelson was a bright spark off the bench against Everton and may give Silva some food for thought.
Fulham possible starting lineup:
Leno; Tete, Andersen, Bassey, Robinson; Berge, Pereira; Traore, Smith Rowe, Iwobi; Jimenez