The Red Devils ended a five-game winless run across all competitions, including two Europa League draw with FC Twente and Porto, by beating Brentford 2-1 on home soil in the Premier League last weekend.
Erik ten Hag's side are now bidding to win back-to-back games for just the second time this season when they square off against Fenerbahce, who have picked up four points from their opening two Europa League fixtures this term.
Here, Sports Mole rounds up Man United's latest injury and suspension news ahead of the contest with Mourinho's men.
Leny Yoro
Status: Out
Type of injury: Foot
Possible return date: November 24 (vs. Ipswich)
Man United have been boosted by the news that summer signing Leny Yoro has returned to training and has advanced to the 'next phase' of his recovery from a fractured metatarsal. However, the teenager is not expected to make his first-team comeback until the end of next month.
Kobbie Mainoo
Status: Out
Type of injury: Muscle
Possible return date: November 10 (vs. Leicester)
Man United confirmed prior to their win at Brentford that Kobbie Mainoo is ruled out for 'a few weeks' with a muscle injury.
Harry Maguire
Status: Out
Type of injury: Muscle
Possible return date: November 10 (vs. Leicester)
Man United confirmed prior to their win at Brentford that Harry Maguire is ruled out for 'a few weeks' with a muscle injury.
Luke Shaw
Status: Out
Type of injury: Calf
Possible return date: Unknown
Luke Shaw is yet to play for Man United this season due to a troublesome calf injury and it remains unknown as to when the left-back will return to Ten Hag's side.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Tyrell Malacia missed the entire 2023-24 season with a serious knee injury which required two separate operations. The left-back has since returned to training, but he is not yet ready to make his long-awaited comeback.
Mason Mount
Status: Out
Type of injury: Knock
Possible return date: Unknown
Mason Mount has missed Man United's last three matches with an unspecified knock and it remains to be seen when he will be ready to return to the first-team fold.
Tom Collyer
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Tom Collyer was absent from Man United's win over Brentford due to an unspecified injury and it remains unknown as to when the midfielder will be ready to return.
Casemiro
Status: Minor doubt
Type of injury: Calf
Possible return date: October 24 (vs. Fenerbahce)
Casemiro was taken off in the closing stages of Man United's win over Brentford with an apparent calf injury. After the match, Ten Hag did not provide an update on the Brazilian, who is set to be assessed ahead of Thursday's fixture.
MANCHESTER UNITED's SUSPENSION LIST
Bruno Fernandes
Status: Out
Return date in Europa League: November 11 (vs. PAOK)
Manchester United will have to cope without club captain Bruno Fernandes, who is to serve a one-match suspension after receiving two yellow cards in the 3-3 draw with Porto three weeks ago.