The home side fell further behind in the title race last time out and will need a better result than Galatasaray this weekend to mathematically remain in contention.
Match preview
Fenerbahce suffered another blow in the title race, now trailing league leaders Galatasaray by six points after a goalless draw with Konyaspor at the Torku Arena.
With three matches remaining, Ismail Kartal's men must ensure Galatasaray does not record a better result this weekend if they are to stay in the hunt.
The Yellow Canaries were top of the table for a significant period before conceding the lead recently. Their chances of dethroning their rivals as champions are now slim following two draws in their last three matches.
The hosts have won their last five encounters against Sunday's opponents in all competitions, with their last league defeat to Kayserispor coming in 2019. However, having already dropped points in four home matches this season, complacency will not be an option for Fenerbahce.
Kayserispor salvaged a 2-2 draw against Fatih Karagumruk last Saturday, boosting their chances of survival in the league.
The Anatolian Stars took the lead through Carlos Mane in the second minute but surrendered it in the second half before Aylton Boa Morte restored parity five minutes past the hour mark.
Burak Yilmaz's side currently sit 13th in the table with 41 points from 35 matches, six points clear of the relegation zone.
Kayserispor finished with 47 points last season and will hope to equal that tally with three games remaining. However, their last away league win at Fenerbahce came in 2018.
Fenerbahce Turkish Super Lig form:
W
W
W
D
W
D
Fenerbahce form (all competitions):
L
W
L
D
W
D
Kayserispor Turkish Super Lig form:
L
L
D
L
W
D
Team News
The hosts will be without Jayden Oosterwolde and Ryan Kent, who are both sidelined with knee injuries.
Edin Dzeko is second on the scorer's chart with 20 goals and will hope to add more to his tally as he is three goals behind in the golden boot race.
The visitors are expected to remain without Anthony Uzodimma and Majid Hosseini who are currently nursing long-term injuries, with neither expected back in the near future.
Julian Jeanvier is battling a knee injury, while Ali Karimi is out of the season with a ligament issue.
Fenerbahce possible starting lineup:
Livakovic; Kadioglu, Djiku, Becao, Osayi-Samuel; Fred, Yuksek; Tadic, Szymanski, Kahveci; Dzeko
Kayserispor possible starting lineup:
Bayazit; Civelek, Kolovetsios, Kocaman, Sazdagi; Yilmaz, Cardoso; Mane, Shukurov, Boa Morte; Nazon