Meanwhile, the Toffees will be looking to produce a positive response after falling to a heavy defeat in their WSL opener against Brighton & Hove Albion.
Match preview
Everton produced a strong finish to the 2023-24 season, winning two and drawing two of their final four league games to end the season in eighth spot.
Toffees boss Brian Sorensen would have hoped his team would be able to pick up from where they left off last term, but their opening-day trip to Broadfield Stadium ultimately proved to be a forgettable experience.
Brighton's Kiko Seike netted a hat-trick alongside a Fran Kirby effort to condemn the Toffees to a 4-0 defeat, with the result representing their heaviest loss since losing 5-0 to Man United in October 2023.
The Toffees will hope to bounce back in their first home game of the season, but they will certainly have their work cut out after drawing two and losing eight of their previous 10 WSL meetings with Man United.
Everton have also gone four WSL home matches since recording their most recent top-flight home game against West Ham United in February.
Meanwhile, Man United are hoping for improved fortunes in the WSL this season after they had to settle for an underwhelming fifth-place finish last term.
While it is too early to draw too many conclusions, the Red Devils would have been encouraged by their dominant performance in their WSL opener against West Ham.
Geyse and Leah Galton grabbed a goal apiece to give Man United a half-time lead, before Grace Clinton found the net in the second period to mark her debut with a goal.
After kicking off the campaign with a 3-0 win, the Red Devils will head on their travels knowing that they need to do better on the road this season after winning just one of their final six away league games of the 2023-24 campaign.
They will certainly fancy their chances of claiming all three points against Everton due to the fact they recorded three head-to-head victories last term, clinching a 5-0 away win in the league before winning 7-0 and 4-1 at home in the League Cup and the WSL respectively.
Everton Women Women's Super League form:
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W
D
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W
L
Manchester United Women Women's Super League form:
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D
W
L
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W
Manchester United Women form (all competitions):
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W
Team News
Everton have been handed a major injury blow after it was confirmed that Aurora Galli sustained an anterior cruciate ligament (ACL) injury in the defeat to Brighton.
In addition to Galli, the Toffees are also expected to be without the services of Emily Ramsey, Melissa Lawley and Karen Holmgaard.
Summer signing Honoka Hayashi could make her first Everton start after coming off the bench to make her debut last weekend.
Meanwhile Man United are unable to call upon defender Evie Rabjohn, who sustained an ACL injury on international duty with the England Under-19s in the summer.
Man United boss Marc Skinner could be tempted to select the same lineup that started the dominant victory over West Ham.
Elisabeth Terland, who scored 13 league goals for Brighton last term, will look to open her Man United account when she makes her second start for her new club.
Everton Women possible starting lineup:
Brosnan; Vanhaevermaet, Finnigan, Stenevik, S Holmgaard; Payne, Gabarro, Wheeler, Hayashi, Sarri; Snoeijs
Manchester United Women possible starting lineup:
Tullis-Joyce; Riviere, Le Tissier, Turner, Galton; Naalsund, Janssen; Geyse, Clinton, Toone; Terland